05-04-2020, 08:51 AM
(Esta publicação foi modificada pela última vez: 05-04-2020, 08:58 AM por Neo Solid.)
Conforme seria esperado, o vírus está sofrendo mutações, e "melhorando":
RBD mutations from circulating SARS-CoV-2 strains enhance the structural stability and human ACE2 affinity of the spike protein
https://www.biorxiv.org/content/10.1101/...5.991844v2
The receptor binding domain (RBD) of the SARS-CoV-2 S protein plays the key role in the tight binding to human receptor ACE2 for viral entry. Here, we analyzed the worldwide RBD mutants and found 18 mutant strains fell into 8 mutation types under high positive selection pressure during the spread. The equilibrium dissociation constant (KD) of three types of RBD mutants emerging in Wuhan, Shenzhen, Hong Kong and France were two orders of magnitude lower than the prototype Wuhan-Hu-1 strain due to the stabilization of the beta-sheet scaffold of the RBD. This indicated that the mutated viruses may have evolved to acquire remarkably increased infectivity. Five France isolates and one Hong Kong isolate shared the same RBD mutation enhancing the binding affinity,
As cepas, ou versões que conectam melhor na enzima/proteína ACE2 (ECA2 aqui), acabam infectando mais e consequentemente se espalhando mais.
RBD mutations from circulating SARS-CoV-2 strains enhance the structural stability and human ACE2 affinity of the spike protein
https://www.biorxiv.org/content/10.1101/...5.991844v2
The receptor binding domain (RBD) of the SARS-CoV-2 S protein plays the key role in the tight binding to human receptor ACE2 for viral entry. Here, we analyzed the worldwide RBD mutants and found 18 mutant strains fell into 8 mutation types under high positive selection pressure during the spread. The equilibrium dissociation constant (KD) of three types of RBD mutants emerging in Wuhan, Shenzhen, Hong Kong and France were two orders of magnitude lower than the prototype Wuhan-Hu-1 strain due to the stabilization of the beta-sheet scaffold of the RBD. This indicated that the mutated viruses may have evolved to acquire remarkably increased infectivity. Five France isolates and one Hong Kong isolate shared the same RBD mutation enhancing the binding affinity,
As cepas, ou versões que conectam melhor na enzima/proteína ACE2 (ECA2 aqui), acabam infectando mais e consequentemente se espalhando mais.
